Evaluating the severity of 6-hydroxydopamine induced Parkinson’s disease in diabetic rats

Dissertant

Ubayd, Hibah Jabir Subhi

Thesis advisor

Abu Rumaylah, Amjad

University

Isra University

Faculty

Faculty of Pharmacy

University Country

Jordan

Degree

Master

Degree Date

2020

English Abstract

Introduction: Parkinson’s disease and Diabetes Mellitus are both age related diseases.

A debate related to the association between them started in the early sixties.

Today, this possible link is still under study and of interest.

Several studies described that the symptoms of Parkinson’s disease get worse after the onest of Diabetes Mellitus.

Inflammation, mitochondrial dysfunction and oxidative stress are shared pathological mechanisms between neurodegenerative disorders (parkinson’s disease) and diabetes mellitus.

Aim: The aim of this study is to understand the relationship between Parkinson’s disease and diabetes Mellitus.

This may be achieved by examination the ability of 6- OHDA ,which is neurotoxic to damage dopaminergic neurons in presence of diabetes.

Method: Male rats weighing between (220-250) were divided into four groups.

Group A was a control and injected with vehicle only.

Group B animals were given intraperitoneal streptozocin to induce diabetes.

Group C was injected with intracerebral 6-OHDA alone and group D was subjected to 6-OHDA + streptozocin three days before surgery.

The lesion severity was assessd neurochemically and behaviorally.

Result: Fourteen days after intracerebral injection of 6-OHDA and after apomorphine rotation test, 6-OHDA lesioned rats that receive streptozocin showed significantly higher number of rotations in comparison to 6-OHDA alone group.

Additionally, striatal dopamine concentration was lower in 6-OHDA+ streptozocin treated rats versus other groups .

Conclusion: This work suggests that diabetes mellitus accelerate neurodegeneration and put subjects at high risk for Parkinson’

Main Topic

Pharmacology

No. of Pages

66

Table of Contents

Table of contents.

Abstract.

Abstract in Arabic.

Chapter One : Introduction.

Chapter Two : Literature review.

Chapter Three : Materials and methods.

Chapter Four : Results.

Chapter Five : Discussion.

References.

American Psychological Association (APA)

Ubayd, Hibah Jabir Subhi. (2020). Evaluating the severity of 6-hydroxydopamine induced Parkinson’s disease in diabetic rats. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-985103

Modern Language Association (MLA)

Ubayd, Hibah Jabir Subhi. Evaluating the severity of 6-hydroxydopamine induced Parkinson’s disease in diabetic rats. (Master's theses Theses and Dissertations Master). Isra University. (2020).
https://search.emarefa.net/detail/BIM-985103

American Medical Association (AMA)

Ubayd, Hibah Jabir Subhi. (2020). Evaluating the severity of 6-hydroxydopamine induced Parkinson’s disease in diabetic rats. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-985103

Language

English

Data Type

Arab Theses

Record ID

BIM-985103