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Anaplasma phagocytophilum and Anaplasma marginale Elicit Different Gene Expression Responses in Cultured Tick Cells
Joint Authors
Kocan, Katherine M.
Naranjo, Victoria
Massung, Robert F.
Manzano-Roman, Raúl
de la Fuente, José
Blouin, Edmour F.
Jongejan, Frans
Almazán, Consuelo
Zivkovic, Zorica
Source
International Journal of Genomics
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes obligate tick-transmitted intracellular organisms, Anaplasma phagocytophilum and Anaplasma marginale that multiply in both vertebrate and tick host cells.
Recently, we showed that A.
marginale affects the expression of tick genes that are involved in tick survival and pathogen infection and multiplication.
However, the gene expression profile in A.
phagocytophilum-infected tick cells is currently poorly characterized.
The objectives of this study were to characterize tick gene expression profile in Ixodes scapularis ticks and cultured ISE6 cells in response to infection with A.
phagocypthilum and to compare tick gene expression responses in A.
phagocytophilum- and A.
marginale-infected tick cells by microarray and real-time RT-PCR analyses.
The results of these studies demonstrated modulation of tick gene expression by A.
phagocytophilum and provided evidence of different gene expression responses in tick cells infected with A.
phagocytophilum and A.
marginale.
These differences in Anaplasma-tick interactions may reflect differences in pathogen life cycle in the tick cells.
American Psychological Association (APA)
Zivkovic, Zorica& Blouin, Edmour F.& Manzano-Roman, Raúl& Almazán, Consuelo& Naranjo, Victoria& Massung, Robert F.…[et al.]. 2009. Anaplasma phagocytophilum and Anaplasma marginale Elicit Different Gene Expression Responses in Cultured Tick Cells. International Journal of Genomics،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988529
Modern Language Association (MLA)
Zivkovic, Zorica…[et al.]. Anaplasma phagocytophilum and Anaplasma marginale Elicit Different Gene Expression Responses in Cultured Tick Cells. International Journal of Genomics No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-988529
American Medical Association (AMA)
Zivkovic, Zorica& Blouin, Edmour F.& Manzano-Roman, Raúl& Almazán, Consuelo& Naranjo, Victoria& Massung, Robert F.…[et al.]. Anaplasma phagocytophilum and Anaplasma marginale Elicit Different Gene Expression Responses in Cultured Tick Cells. International Journal of Genomics. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988529