Cytokine Expression in CD3+ Cells in an Infant with Food Protein-Induced Enterocolitis Syndrome (FPIES): Case Report
Joint Authors
Barni, S.
Novembre, E.
Cianferoni, A.
Pucci, N.
Mori, F.
de Martino, M.
Source
Journal of Immunology Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy characterized by severe vomiting, diarrhea, and often failure to thrive in infants.
Symptoms typically resolve after the triggering food-derived protein is removed from the diet and recur within few hours after the re-exposure to the causal protein.
The diagnosis is based on clinical symptoms and a positive food challenge.
In this study, we report a case of FPIES to rice in an 8-month-old boy.
We performed a double-blind placebo-controlled food challenge (DBPCFC) to rice and we measured the intracellular T cell expression of interleukin-4 (IL-4); IL-10, and interferon γ (IFN-γ) pre-and post-challenge during an acute FPIES reaction and when tolerance to rice had been achieved.
For the first time we describe an increase in T cell IL-4 and decrease in IFN-γ expression after a positive challenge with rice (i.e.
rice triggered a FPIES attack) and an increase in T cell IL-10 expression after rice challenge 6 months later after a negative challenge (i.e., the child had acquired tolerance to rice) in an 8 month old with documented FPIES to rice.
A Th2 activation associated with high IL-4 levels may contribute to the pathophysiology of the disease.
On the other hand, T cell-derived IL-10 may play a role in the acquisition of immunotolerance by regulating the Th1 and Th2 responses.
American Psychological Association (APA)
Mori, F.& Barni, S.& Cianferoni, A.& Pucci, N.& de Martino, M.& Novembre, E.. 2009. Cytokine Expression in CD3+ Cells in an Infant with Food Protein-Induced Enterocolitis Syndrome (FPIES): Case Report. Journal of Immunology Research،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-988619
Modern Language Association (MLA)
Mori, F.…[et al.]. Cytokine Expression in CD3+ Cells in an Infant with Food Protein-Induced Enterocolitis Syndrome (FPIES): Case Report. Journal of Immunology Research No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-988619
American Medical Association (AMA)
Mori, F.& Barni, S.& Cianferoni, A.& Pucci, N.& de Martino, M.& Novembre, E.. Cytokine Expression in CD3+ Cells in an Infant with Food Protein-Induced Enterocolitis Syndrome (FPIES): Case Report. Journal of Immunology Research. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-988619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988619