Development of a Multicommutated Flow System with Chemiluminometric Detection for Quantification of Gentamicin in Pharmaceuticals
Joint Authors
Montenegro, M. C. B. S. M.
Santos, Lúcia H. M. L. M.
Reis, Boaventura F.
Araújo, A. N.
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A new flow procedure based on multicommutation with chemiluminometric detection was developed to quantify gentamicin sulphate in pharmaceutical formulations.
This approach is based on gentamicin's ability to inhibit the chemiluminometric reaction between luminol and hypochlorite in alkaline medium, causing a decrease in the analytical signal.
The inhibition of the analytical signal is proportional to the concentration of gentamicin sulphate, within a linear range of 1 to 4 μg mL-1 with a coefficient variation <3%.
A sample throughput of 55 samples h-1 was obtained.
The developed method is sensitive, simple, with low reagent consumption, reproducible, and inexpensive, and when applied to the analysis of pharmaceutical formulations (eye drops and injections) it gave results with RSD between 1.10 and 4.40%.
American Psychological Association (APA)
Santos, Lúcia H. M. L. M.& Araújo, A. N.& Reis, Boaventura F.& Montenegro, M. C. B. S. M.. 2010. Development of a Multicommutated Flow System with Chemiluminometric Detection for Quantification of Gentamicin in Pharmaceuticals. Journal of Analytical Methods in Chemistry،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-989243
Modern Language Association (MLA)
Santos, Lúcia H. M. L. M.…[et al.]. Development of a Multicommutated Flow System with Chemiluminometric Detection for Quantification of Gentamicin in Pharmaceuticals. Journal of Analytical Methods in Chemistry No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-989243
American Medical Association (AMA)
Santos, Lúcia H. M. L. M.& Araújo, A. N.& Reis, Boaventura F.& Montenegro, M. C. B. S. M.. Development of a Multicommutated Flow System with Chemiluminometric Detection for Quantification of Gentamicin in Pharmaceuticals. Journal of Analytical Methods in Chemistry. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-989243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989243