Tumor Antigen-Dependent and Tumor Antigen-Independent Activation of Antitumor Activity in T Cells by a Bispecific Antibody-Modified Tumor Vaccine
Joint Authors
Schirrmacher, Volker
Fournier, Philippe
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
New approaches of therapeutic cancer vaccination are needed to improve the antitumor activity of T cells from cancer patients.
We studied over the last years the activation of human T cells for tumor attack.
To this end, we combined the personalized therapeutic tumor vaccine ATV-NDV—which is obtained by isolation, short in vitro culture, irradiation, and infection of patient's tumor cells by Newcastle Disease Virus (NDV)—with bispecific antibodies (bsAbs) binding to this vaccine and introducing anti-CD3 (signal 1) and anti-CD28 (signal 2) antibody activities.
This vaccine called ATV-NDV/bsAb showed the unique ability to reactivate a preexisting potentially anergized antitumor memory T cell repertoire.
But it also activated naive T cells to have antitumor properties in vitro and in vivo.
This innovative concept of direct activation of cancer patients' T cells via cognate and noncognate interactions provides potential for inducing strong antitumor activities aiming at overriding T cell anergy and tumor immune escape mechanisms.
American Psychological Association (APA)
Fournier, Philippe& Schirrmacher, Volker. 2010. Tumor Antigen-Dependent and Tumor Antigen-Independent Activation of Antitumor Activity in T Cells by a Bispecific Antibody-Modified Tumor Vaccine. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989308
Modern Language Association (MLA)
Fournier, Philippe& Schirrmacher, Volker. Tumor Antigen-Dependent and Tumor Antigen-Independent Activation of Antitumor Activity in T Cells by a Bispecific Antibody-Modified Tumor Vaccine. Journal of Immunology Research No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-989308
American Medical Association (AMA)
Fournier, Philippe& Schirrmacher, Volker. Tumor Antigen-Dependent and Tumor Antigen-Independent Activation of Antitumor Activity in T Cells by a Bispecific Antibody-Modified Tumor Vaccine. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989308