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Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis
Joint Authors
Granato, Anna Maria
Petrini, Massimiliano
Verdecchia, Giorgio Maria
Migliori, Giuseppe
Ridolfi, Ruggero
Riccobon, Angela
Ancarani, Valentina
Tauceri, Francesca
Scarpi, Emanuela
Ridolfi, Laura
Pancisi, Elena
Fiammenghi, Laura
Sanna, Stefano
Guidoboni, Massimo
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We reviewed the clinical results of a dendritic cell-based phase II clinical vaccine trial in stage IV melanoma and analyzed a patient subgroup treated with standard therapies after stopping vaccination.
From 2003 to 2009, 24 metastatic melanoma patients were treated with mature dendritic cells pulsed with autologous tumor lysate and keyhole limpet hemocyanin and low-dose interleukin-2.
Overall response (OR) to vaccination was 37.5% with a clinical benefit of 54.1%.
All 14 responders showed delayed type hypersensitivity positivity.
Median overall survival (OS) was 15 months (95% CI, 8–33).
Eleven patients underwent other treatments (3 surgery, 2 biotherapy, 2 radiotherapy, 2 chemotherapy, and 4 biochemotherapy) after stopping vaccination.
Of these, 2 patients had a complete response and 5 a partial response, with an OR of 63.6%.
Median OS was 34 months (range 16–61).
Our results suggest that therapeutic DC vaccination could favor clinical response in patients after more than one line of therapy.
American Psychological Association (APA)
Ridolfi, Laura& Petrini, Massimiliano& Fiammenghi, Laura& Granato, Anna Maria& Ancarani, Valentina& Pancisi, Elena…[et al.]. 2010. Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989313
Modern Language Association (MLA)
Ridolfi, Laura…[et al.]. Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis. Journal of Immunology Research No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989313
American Medical Association (AMA)
Ridolfi, Laura& Petrini, Massimiliano& Fiammenghi, Laura& Granato, Anna Maria& Ancarani, Valentina& Pancisi, Elena…[et al.]. Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989313