Antihypertriglyceridemia and Anti-Inflammatory Activities of Monascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats
Joint Authors
Liao, Jiunn-Wang
Shi, Yeu-Ching
Pan, Tzu-Ming
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The rice fermented by Monascus, called red mold rice (RMR), and has a long tradition in East Asia as a dietary staple.
Monascus-fermented dioscorea called red mold dioscorea (RMD) contains various metabolites to perform the ability of reducing oxidative stress and anti-inflammatory response.
We used Wistar rats and induced diabetes by injecting streptozotocin (STZ, 65 mg/kg i.p.).
RMD was administered daily starting six weeks after disease onset.
Throughout the experimental period, significantly (P<.05) lowered plasma glucose, triglyceride, cholesterol, free fatty acid and low density lipoprotein levels were observed in the RMD-treated groups.
The RMD-treated diabetic rats showed higher activities of glutathione disulfide reductase, glutathione reductase, catalase and superoxide dismutase (P<.05) in the pancreas compared with the diabetic control rats.
RMD also inhibited diabetes-induced elevation in the levels of interleukin (IL)-1β, IL-6, interferon-γ and tumor necrosis factor-α.
Pancreatic β-cells damaged by STZ in the RMD supplemented groups were ameliorated.
The results of this study clearly demonstrated that RMD possesses several treatment-oriented properties, including the control of hyperglycemia, antioxidant effects, pancreatic β-cell protection and anti-inflammatory effects.
Considering these observations, it appears that RMD may be a useful supplement to delay the development of diabetes and its complications.
American Psychological Association (APA)
Shi, Yeu-Ching& Liao, Jiunn-Wang& Pan, Tzu-Ming. 2011. Antihypertriglyceridemia and Anti-Inflammatory Activities of Monascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990681
Modern Language Association (MLA)
Shi, Yeu-Ching…[et al.]. Antihypertriglyceridemia and Anti-Inflammatory Activities of Monascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-990681
American Medical Association (AMA)
Shi, Yeu-Ching& Liao, Jiunn-Wang& Pan, Tzu-Ming. Antihypertriglyceridemia and Anti-Inflammatory Activities of Monascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990681