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Chloroform Extract of Rasagenthi Mezhugu, a Siddha Formulation, as an Evidence-Based Complementary and Alternative Medicine for HPV-Positive Cervical Cancers
Joint Authors
Riyasdeen, Anvarbatcha
Periasamy, Vaiyapuri S.
Paul, Preethy
Alshatwi, Ali A.
Akbarsha, Mohammad A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rasagenthi Mezhugu (RGM) is a herbomineral formulation in the Siddha system of traditional medicine and is prescribed in the southern parts of India as a remedy for all kinds of cancers.
However, scientific evidence for its therapeutic efficacy in cervical cancer is lacking, and it contains heavy metals.
To overcome these limitations, RGM was extracted, and the fractions were tested on HPV-positive cervical cancer cells, ME-180 and SiHa.
The extracts, free from the toxic heavy metals, affected the viability of both the cells.
The chloroform fraction (cRGM) induced DNA damage and apoptosis.
Mitochondria-mediated apoptosis was indicated.
Though both the cells responded to the treatment, ME-180 was more responsive.
Thus, this study brings up scientific evidence for the efficacy of RGM against the HPV-mediated cervical cancer cells and, if the toxic heavy metals are the limitation in its use, cRGM would be a suitable candidate as evidence-based complementary and alternative medicine for HPV-positive cervical cancers.
American Psychological Association (APA)
Riyasdeen, Anvarbatcha& Periasamy, Vaiyapuri S.& Paul, Preethy& Alshatwi, Ali A.& Akbarsha, Mohammad A.. 2011. Chloroform Extract of Rasagenthi Mezhugu, a Siddha Formulation, as an Evidence-Based Complementary and Alternative Medicine for HPV-Positive Cervical Cancers. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992026
Modern Language Association (MLA)
Riyasdeen, Anvarbatcha…[et al.]. Chloroform Extract of Rasagenthi Mezhugu, a Siddha Formulation, as an Evidence-Based Complementary and Alternative Medicine for HPV-Positive Cervical Cancers. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992026
American Medical Association (AMA)
Riyasdeen, Anvarbatcha& Periasamy, Vaiyapuri S.& Paul, Preethy& Alshatwi, Ali A.& Akbarsha, Mohammad A.. Chloroform Extract of Rasagenthi Mezhugu, a Siddha Formulation, as an Evidence-Based Complementary and Alternative Medicine for HPV-Positive Cervical Cancers. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992026
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992026