Hepatoprotective Activity of Elephantopus scaber on Alcohol-Induced Liver Damage in Mice
Joint Authors
Alitheen, Noorjahan Banu Mohamed
Ho, Chai Ling
Ho, Wan Yong
Abdul Rahim, Raha
Yeap, Swee Keong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Elephantopus scaber has been traditionally used as liver tonic.
However, the protective effect of E.
scaber on ethanol-induced liver damage is still unclear.
In this study, we have compared the in vivo hepatoprotective effect of E.
scaber with Phyllanthus niruri on the ethanol-induced liver damage in mice.
The total phenolic and total flavanoid content of E.
scaber ethanol extract were determined in this study.
Accelerating serum biochemical profiles (including AST, ALT, ALP, triglyceride, and total bilirubin) associated with fat drop and necrotic body in the liver section were observed in the mice treated with ethanol.
Low concentration of E.
scaber was able to reduce serum biochemical profiles and the fat accumulation in the liver.
Furthermore, high concentration of E.
scaber and positive control P.
niruri were able to revert the liver damage, which is comparable to the normal control.
Added to this, E.
scaber did not possess any oral acute toxicity on mice.
These results suggest the potential effect of this extract as a hepatoprotective agent towards-ethanol induced liver damage without any oral acute toxicity effect.
These activities might be contributed, or at least in part, by its high total phenolic and flavonoid contents.
American Psychological Association (APA)
Ho, Wan Yong& Yeap, Swee Keong& Ho, Chai Ling& Abdul Rahim, Raha& Alitheen, Noorjahan Banu Mohamed. 2012. Hepatoprotective Activity of Elephantopus scaber on Alcohol-Induced Liver Damage in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992266
Modern Language Association (MLA)
Ho, Wan Yong…[et al.]. Hepatoprotective Activity of Elephantopus scaber on Alcohol-Induced Liver Damage in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992266
American Medical Association (AMA)
Ho, Wan Yong& Yeap, Swee Keong& Ho, Chai Ling& Abdul Rahim, Raha& Alitheen, Noorjahan Banu Mohamed. Hepatoprotective Activity of Elephantopus scaber on Alcohol-Induced Liver Damage in Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992266