Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice
Author
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims of study.
Present study investigated the effect of Ecklonia cava (EC) on intestinal glucose uptake and insulin secretion.
Materials and methods.
Intestinal Na+-dependent glucose uptake (SGU) and Na+-dependent glucose transporter 1 (SGLT1) protein expression was determined using brush border membrane vesicles (BBMVs).
Glucose-induced insulin secretion was examined in pancreatic β-islet cells.
The antihyperglycemic effects of EC, SGU, and SGLT1 expression were determined in streptozotocin (STZ)-induced diabetic mice.
Results.
Methanol extract of EC markedly inhibited intestinal SGU of BBMV with the IC50 value of 345 μg/mL.
SGLT1 protein expression was dose dependently down regulated with EC treatment.
Furthermore, insulinotrophic effect of EC extract was observed at high glucose media in isolated pancreatic β-islet cells in vitro.
We next conducted the antihyperglycemic effect of EC in STZ-diabetic mice.
EC supplementation markedly suppressed SGU and SGLT1 abundance in BBMV from STZ mice.
Furthermore, plasma insulin level was increased by EC treatment in diabetic mice.
As a result, EC supplementation improved postprandial glucose regulation, assessed by oral glucose tolerance test, in diabetic mice.
Conclusion.
These results suggest that EC play a role in controlling dietary glucose absorption at the intestine and insulinotrophic action at the pancreas contributing blood glucose homeostasis in diabetic condition.
American Psychological Association (APA)
Kim, Hye Kyung. 2012. Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992297
Modern Language Association (MLA)
Kim, Hye Kyung. Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992297
American Medical Association (AMA)
Kim, Hye Kyung. Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992297