Cardioprotective Effect of the Compound Yangshen Granule in Rat Models with Acute Myocardial Infarction
Joint Authors
Ming, Xie
Tongshen, Wang
Delin, Wu
Ronghua, Zhao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The protective effect of Compound Yangshen Granules was observed in myocardial infarction rat model.
Rats were randomly divided into 6 groups: the model group, the control group (sham operated), the positive drug group, and small, medium, and large dosage of the Yangshen granule groups, respectively.
The rats in the 3 Yangshen granule groups were orally administrated with 0.7 g/kg, 1.4 g/kg, and 2.8 g/kg for 7 consecutive days, whereas the rats of the positive drug group treated with 0.14 g/kg of Danshen Dropping Pills, and rats in the control and model groups orally administrated with saline.
The rat model of acute myocardial infarction was established with ligation of coronary artery.
Electrocardiograms at different time points, the blood rheology, myocardial enzymes, infarct size, and myocardial morphologic changes were measured.
The results demonstrated that the granules could improve blood rheology, decrease st-segment of electrocardiograms and the activities of LDH and CK in serum, reduce myocardial infarction size, and alleviate myocardial histopathologic changes.
In addition, the effect of the granules depended on the dose administrated orally.
The results suggest that the Yangshen granules could produce cardioprotection effect and have potential benefits in the prevention of ischemic heart disease.
American Psychological Association (APA)
Ming, Xie& Tongshen, Wang& Delin, Wu& Ronghua, Zhao. 2012. Cardioprotective Effect of the Compound Yangshen Granule in Rat Models with Acute Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992578
Modern Language Association (MLA)
Ming, Xie…[et al.]. Cardioprotective Effect of the Compound Yangshen Granule in Rat Models with Acute Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-992578
American Medical Association (AMA)
Ming, Xie& Tongshen, Wang& Delin, Wu& Ronghua, Zhao. Cardioprotective Effect of the Compound Yangshen Granule in Rat Models with Acute Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992578