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Comparison of Effects of the Ethanolic Extracts of Brazilian Propolis on Human Leukemic Cells As Assessed with the MTT Assay
Joint Authors
Franchi, Gilberto C.
Moraes, Cleber S.
Toreti, Viviane C.
Daugsch, Andreas
Nowill, Alexandre E.
Park, Yong Kun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Propolis is a resinous product collected by honey bees.
It was also reported that propolis has a wide variety of biological actions, including antimicrobial activity and antioxidant, anti-inflammatory, and suppressive effects of dioxin toxicity activities.
The aim of this study was to compare the in vitro cytotoxic activities of green propolis (G12) and red propolis (G13) in human leukemia cells.
These cells were incubated with different concentrations of propolis and 48 hours after the IC50 was calculated for each cell.
The results showed that the red propolis has cytotoxic effect in vitro higher than green propolis.
Red propolis was showed to be cytostatic in K562 cells and caused the same amount of apoptosis as its control Gleevec.
In conclusion, these results showed that red propolis is more cytotoxic than the green propolis in a variety of human cell lines of leukemia.
Red propolis may contain drugs capable of inhibiting cancer cell growth.
Therefore, further isolation of respective chemical ingredients from the red propolis (G13) for identification of the activities is necessary.
American Psychological Association (APA)
Franchi, Gilberto C.& Moraes, Cleber S.& Toreti, Viviane C.& Daugsch, Andreas& Nowill, Alexandre E.& Park, Yong Kun. 2011. Comparison of Effects of the Ethanolic Extracts of Brazilian Propolis on Human Leukemic Cells As Assessed with the MTT Assay. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992770
Modern Language Association (MLA)
Franchi, Gilberto C.…[et al.]. Comparison of Effects of the Ethanolic Extracts of Brazilian Propolis on Human Leukemic Cells As Assessed with the MTT Assay. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-992770
American Medical Association (AMA)
Franchi, Gilberto C.& Moraes, Cleber S.& Toreti, Viviane C.& Daugsch, Andreas& Nowill, Alexandre E.& Park, Yong Kun. Comparison of Effects of the Ethanolic Extracts of Brazilian Propolis on Human Leukemic Cells As Assessed with the MTT Assay. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992770