Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis
Joint Authors
Shuid, Ahmad Nazrun
Fathilah, Siti Noor
Abdullah, Shahrum
Mohamed, Norazlina
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Estrogen replacement therapy (ERT) is the main treatment postmenopausal osteoporosis.
However, ERT causes serious side effects, such as cancers and thromboembolic problems.
Labisia pumila var.
alata (LPva) is a herb with potential as an alternative to ERT to prevent complications of osteoporosis, especially fragility fractures.
This study was conducted to determine the effects of LPva on the biomechanical strength of femora exposed to osteoporosis due to estrogen deficiency, using the postmenopausal rat model.
Thirty-two female rats were randomly divided into four groups: Sham-operated (Sham), ovariectomized control (OVXC), ovariectomized with Labisia pumila var.
alata (LP), and ovariectomized with ERT (Premarin) (ERT).
The LPva and ERT were administered via oral gavage daily at doses of 17.5 mg/kg and 64.5 μg/kg, respectively.
Following two months of treatment, the rats were euthanized, and their right femora were prepared for bone biomechanical testing.
The results showed that ovariectomy compromised the femoral strength, while LPva supplementation to the ovariectomized rats improved the femoral strength.
Therefore, LPva may be as effective as ERT in preventing fractures due to estrogen-deficient osteoporosis.
American Psychological Association (APA)
Fathilah, Siti Noor& Abdullah, Shahrum& Mohamed, Norazlina& Shuid, Ahmad Nazrun. 2012. Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992807
Modern Language Association (MLA)
Fathilah, Siti Noor…[et al.]. Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992807
American Medical Association (AMA)
Fathilah, Siti Noor& Abdullah, Shahrum& Mohamed, Norazlina& Shuid, Ahmad Nazrun. Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992807