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Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model
Joint Authors
Kadowaki, Makoto
Yamamoto, Takeshi
Kodama, Toshihisa
Tsubota, Yuma
Kageyama-Yahara, Natsuko
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We examined whether maternal exposure to food antigens during lactation and maternal allergic status would affect the development of food allergy in offspring.
OVA-sensitized or OVA-nonsensitized BALB/c female mice were exposed or unexposed to OVA during lactation.
After weaning, their offspring were systemically sensitized twice with OVA and repeatedly given OVA by oral intubation.
While 97.1% of the mice breastfed by OVA-nonsensitized and OVA-unexposed mothers developed allergic diarrhea, 59.7% of the mice breastfed by OVA-exposed nonallergic mothers during lactation and 24.6% of the mice breastfed by OVA-exposed allergic mothers during lactation developed food allergy.
Furthermore, OVA was detected in breast-milk from OVA-exposed nonallergic mothers during lactation (4.6±0.5 μg/mL).
In addition, OVA-specific IgG1 titers were markedly increased in breast milk from allergic mothers (OVA-sensitized and OVA-unexposed mother: 11.0±0.5, OVA-sensitized and OVA-exposed mother: 12.3±0.3).
Our results suggest that oral tolerance induced by breast milk-mediated transfer of dietary antigens along with their specific immunoglobulins to offspring leads to antigen-specific protection from food allergy.
American Psychological Association (APA)
Yamamoto, Takeshi& Tsubota, Yuma& Kodama, Toshihisa& Kageyama-Yahara, Natsuko& Kadowaki, Makoto. 2012. Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996799
Modern Language Association (MLA)
Yamamoto, Takeshi…[et al.]. Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-996799
American Medical Association (AMA)
Yamamoto, Takeshi& Tsubota, Yuma& Kodama, Toshihisa& Kageyama-Yahara, Natsuko& Kadowaki, Makoto. Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996799