Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection
Joint Authors
Azzari, Chiara
Resti, Massimo
Olivito, Biagio
Indolfi, Giuseppe
Bartolini, Elisa
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hepatitis C virus (HCV) infection has been associated with autoimmunity and extrahepatic manifestations in adults.
Few data are available on these topics in children.
Nonorgan specific auto-antibodies development is part of the natural course of chronic hepatitis C in children.
Smooth muscle autoantibody is the most common autoantibody found, while liver-kidney microsomal type-1 antibody positivity is the most peculiar autoimmune feature of children with HCV infection.
The clinical significance of non-organ specific autoantibodies in the course of paediatric chronic hepatitis C is still debated.
Autoantibody positivity can be considered neutral for most patients, while it can be associated with negative connotations for others, especially those positive for liver-kidney microsomal type-1 autoantibody.
Subclinical hypothyroidism but not autoimmune thyroiditis has been demonstrated in HCV infection in children, while only few cases of HCV-associated membranoproliferative glomerulonephritis have been described.
Single reports are available in the literature reporting the anecdotal association between chronic hepatitis C and other extrahepatic manifestations such as myopathy and opsoclonus-myoclonus syndrome.
Despite the low incidence of extrahepatic manifestations of chronic hepatitis C in children, overall, available data suggest a careful monitoring.
American Psychological Association (APA)
Indolfi, Giuseppe& Bartolini, Elisa& Olivito, Biagio& Azzari, Chiara& Resti, Massimo. 2012. Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-996825
Modern Language Association (MLA)
Indolfi, Giuseppe…[et al.]. Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-996825
American Medical Association (AMA)
Indolfi, Giuseppe& Bartolini, Elisa& Olivito, Biagio& Azzari, Chiara& Resti, Massimo. Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-996825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996825