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Preparation and Properties of Biphasic Calcium Phosphate Scaffolds Multiply Coated with HAPLLA Nanocomposites for Bone Tissue Engineering Applications
Joint Authors
Nie, Lei
Suo, Jinping
Zou, Peng
Feng, Shuibin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A well-developed BCP scaffolds coated with multilayer of HA/PLLA nanocomposites with interconnectivity, high porosity, and moderate compressive strength as well as good biocompatibility were fabricated for bone tissue engineering.
After being multiply coated with HA/PLLA nanocomposites, the scaffolds maintained the BCP framework structure, and the porous network structure of scaffolds remained unchanged; however, the compressive strength was increased with the increase of coating layer number of HA/PLLA nanocomposites.
The prepared scaffolds showed lower variation of pH values in SBF solution, and an increase of coating layer number led to the decrease of the biodegradation rate at different days.
Moreover, the multilayer coating scaffolds had good cytocompatibility, showing no negative effects on cells growth and proliferation.
Furthermore, the bone-like apatite layer was built obviously in the interface of scaffold after 21 days after implantation in SD rat muscle.
In conclusion, the BCP scaffold coated with multilayer of HA/PLLA nanocomposites could be a candidate as an excellent substitute for damaged or defect bone in bone tissue engineering.
American Psychological Association (APA)
Nie, Lei& Suo, Jinping& Zou, Peng& Feng, Shuibin. 2012. Preparation and Properties of Biphasic Calcium Phosphate Scaffolds Multiply Coated with HAPLLA Nanocomposites for Bone Tissue Engineering Applications. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-997463
Modern Language Association (MLA)
Nie, Lei…[et al.]. Preparation and Properties of Biphasic Calcium Phosphate Scaffolds Multiply Coated with HAPLLA Nanocomposites for Bone Tissue Engineering Applications. Journal of Nanomaterials No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-997463
American Medical Association (AMA)
Nie, Lei& Suo, Jinping& Zou, Peng& Feng, Shuibin. Preparation and Properties of Biphasic Calcium Phosphate Scaffolds Multiply Coated with HAPLLA Nanocomposites for Bone Tissue Engineering Applications. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-997463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-997463