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Protective effect of moringa olifera leaves extracts and silymarin on hepatic toxicity induced by cyclophosphamide
Other Title(s)
التأثير الوقائي لمستخلصات نبات المورينجا أوليفيرا و سيليمارين ضد سمية الكبد الناجمة عن السيكلوفوسفاميد في الفئران البيضاء
Joint Authors
Ibrahim, Himat Abd al-Fattah
Muntasir, Khadijah K. A.
Ata Allah R. K.
Abd al-Rahim, Muhammad Ahmad Taha
Source
Arab Universities Journal of Agricultural Sciences
Issue
Vol. 27, Issue 4 (30 Sep. 2019), pp.2079-2088, 10 p.
Publisher
Ain Shams University Faculty of Agriculture
Publication Date
2019-09-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
- Liver
- Oxidative Stress
- Activities
- Enzymes
- Blood plasma
- Poisoning
- Aspartate aminotransferase
- Lipid peroxidation
- Uric acid
- Distilled water
- Moringa oleifera
- Barbituric acid
Abstract EN
The leaves of Moringa oleifera plant are documented as active pharmaceutically agent with high antioxidant activity.
In this study the protective effect of ethanolic leaves extract (ELE) and aqueous leaves extract (AQLE) of Moringa oleifera and Silymarin (SIL) were investigated against cyclophosphamide (CYP) injury on liver of rats.
Fifty males of albino rats were divided into five groups, as follows: 1) control group - received distilled water orally; the second group was CYP group which injected with cyclophosphamide at dose of 150 mg/kg through i.
p.
to rats twice; one dose on the15Th day and another on the 30Th day.
Other 3 groups basically injected with CYP as a group 2 Moreover the 3rd group i.
e.
( ELE + CYP) group the rats were administered with ELE at dose 500 mg/kg/day orally through an intra-gastric tube for consecutive 14 days, before and after CYP injection.
The 4Th i.
e.
(AQLE+CYP group) the rats were given AQLE at dose 500 mg/kg/day orally for consecutive 14 days, before and after CYP injection.
5) SIL+CYP group - Rats were administrated with SIL at dose of 100 mg/kg/day by gavage for consecutive 14 days, before and after CYP injection.
One day after the last treatment, blood samples and livers werewc.
collected for histopathological investigations and biochemical determinations.
The level of lipid peroxidation, thiobarbituric acid-reactive substances (TBARS), serum albumin, total protein, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) values were evaluated.
TBARS, AST, ALT, ALP, and LDH in serum were elevated significantly increased (P < 0.05) in CYP group, compared to control group, while total protein and albumin were decreased compared to control group and other groups.
Histopathologically, it was observed hepatocytes damage in CYP induced group compared with the control group and other groups.
In conclusion, Moringa leaves extracts exhibited antioxidant activity by the presence of free radical quenching scavenger constituents which protect liver from cyclophosphamide injury.
American Psychological Association (APA)
Muntasir, Khadijah K. A.& Ibrahim, Himat Abd al-Fattah& Abd al-Rahim, Muhammad Ahmad Taha& Ata Allah R. K.. 2019. Protective effect of moringa olifera leaves extracts and silymarin on hepatic toxicity induced by cyclophosphamide. Arab Universities Journal of Agricultural Sciences،Vol. 27, no. 4, pp.2079-2088.
https://search.emarefa.net/detail/BIM-999916
Modern Language Association (MLA)
Muntasir, Khadijah K. A.…[et al.]. Protective effect of moringa olifera leaves extracts and silymarin on hepatic toxicity induced by cyclophosphamide. Arab Universities Journal of Agricultural Sciences Vol. 27, no. 4 (2019), pp.2079-2088.
https://search.emarefa.net/detail/BIM-999916
American Medical Association (AMA)
Muntasir, Khadijah K. A.& Ibrahim, Himat Abd al-Fattah& Abd al-Rahim, Muhammad Ahmad Taha& Ata Allah R. K.. Protective effect of moringa olifera leaves extracts and silymarin on hepatic toxicity induced by cyclophosphamide. Arab Universities Journal of Agricultural Sciences. 2019. Vol. 27, no. 4, pp.2079-2088.
https://search.emarefa.net/detail/BIM-999916
Data Type
Journal Articles
Language
English
Notes
-
Record ID
BIM-999916