Using pan bread enriched with chia seeds to reduce some side effects of fatty liver induced with fructose in male rats

الملخص EN

Non- alcoholic fatty liver disease (NAFLD) is a metabolic disorder characterized by excessive triglyceride accumulation in hepatocytes.

NAFLD has increased in conjunction with obesity in Egypt.

This research investigated the chemical analysis and sensory evaluation of pan bread and pan bread enriched with Chia seeds and the effects of the consumption of pan bread enriched with Chia seeds on fatty liver rats.

Forty-eight male Albino rats were divided into six groups (n= 8 rats).

The two negative control groups one of them was fed on basal diet and other fed on basal diet with pan bread and 32 rats were fed on basal diet and additional 25 % of fructose in water to induce fatty liver, and reclassified into positive control group which fed on basal diet and pan bread and 3 treated rat groups that treated with 300g Pan bread enriched with various three level (4% , 6% and 8% chia seeds powder / kg diet.

The treated period was designed for 28 days after rat's administrated 25% fructose dissolved in drinking water for 8 weeks for inducing fatty liver.

The Results showed that, Chia seeds contain high amounts of protein, dietary fiber and unsaturated fatty acids.

It is also rich in phenolic compounds which considered as antioxidants.

The results revealed that, the control (+ve) rat group showed significant decrease in body weight, food intak and food efficiency ratio but significant increase in serum (AST, ALT, ALP, GGT), bilirubin, glucose, T.

lipids, TC, TG, LDL-c, urea, creatinine, and tumor necrosis factor (TNF, α) at P≤0.05 in compared with - ve control group and all treated groups.

while all treated rat groups showed significant inecrease in body weight, food intak and food efficiency but significant decrease in serum (AST, ALT, ALP, GGT), bilirubin, glucose, T.

lipids, TC, TG, LDL-c, urea, creatinine, and tumor necrosis factor (TNF, α) at P≤0.05 in compared with +ve control group.

In conclusion, the administration of pan bread enriched with Chia seeds can lower the side effects of fructose to induced fatty liver in rats and improve the healthy status with improved of fatty liver function