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A Comparative Study of the Metabolic and Skeletal Response of C57BL6J and C57BL6N Mice in a Diet-Induced Model of Type 2 Diabetes
المؤلفون المشاركون
Rendina-Ruedy, Elizabeth
Hembree, Kelsey D.
Sasaki, Angela
Davis, McKale R.
Lightfoot, Stan A.
Clarke, Stephen L.
Smith, Brenda J.
Lucas, Edralin A.
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Type 2 diabetes mellitus (T2DM) represents a complex clinical scenario of altered energy metabolism and increased fracture incidence.
The C57BL/6 mouse model of diet-induced obesity has been used to study the mechanisms by which altered glucose homeostasis affects bone mass and quality, but genetic variations in substrains of C57BL/6 may have confounded data interpretation.
This study investigated the long-term metabolic and skeletal consequences of two commonly used C57BL/6 substrains to a high fat (HF) diet.
Male C57BL/6J, C57BL/6N, and the negative control strain, C3H/HeJ, mice were fed a control or HF diet for 24 wks.
C57BL/6N mice on a HF diet demonstrated an increase in plasma insulin and blood glucose as early as 4 wk, whereas these responses were delayed in the C57BL/6J mice.
The C57BL/6N mice exhibited more severe hepatic steatosis and inflammation.
Only the C57BL/6N mice lost significant trabecular bone in response to the high fat diet.
The C3H/HeJ mice were protected from bone loss.
The data show that C57BL/6J and C57BL/6N mice differ in their metabolic and skeletal response when fed a HF diet.
These substrain differences should be considered when designing experiments and are likely to have implications on data interpretation and reproducibility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rendina-Ruedy, Elizabeth& Hembree, Kelsey D.& Sasaki, Angela& Davis, McKale R.& Lightfoot, Stan A.& Clarke, Stephen L.…[et al.]. 2015. A Comparative Study of the Metabolic and Skeletal Response of C57BL6J and C57BL6N Mice in a Diet-Induced Model of Type 2 Diabetes. Journal of Nutrition and Metabolism،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1069522
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rendina-Ruedy, Elizabeth…[et al.]. A Comparative Study of the Metabolic and Skeletal Response of C57BL6J and C57BL6N Mice in a Diet-Induced Model of Type 2 Diabetes. Journal of Nutrition and Metabolism No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1069522
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rendina-Ruedy, Elizabeth& Hembree, Kelsey D.& Sasaki, Angela& Davis, McKale R.& Lightfoot, Stan A.& Clarke, Stephen L.…[et al.]. A Comparative Study of the Metabolic and Skeletal Response of C57BL6J and C57BL6N Mice in a Diet-Induced Model of Type 2 Diabetes. Journal of Nutrition and Metabolism. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1069522
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069522
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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