Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats
المؤلفون المشاركون
Saul, D.
Kling, J. H.
Kosinsky, R. L.
Hoffmann, D. B.
Komrakova, M.
Wicke, M.
Menger, B.
Sehmisch, S.
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-05
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Sarcopenia, a loss of muscle mass accompanying osteoporosis, leads to falls and fall-related injuries.
Baicalein, as a phytochemical agent, has an antioxidative and anti-inflammatory effect in muscle.
In this study, sixty-one female Sprague Dawley rats were divided into five groups: four groups were ovariectomized (OVX) and one control group was nonovariectomized (NON-OVX).
Eight weeks after ovariectomy, three disparate concentrations (1 mg/kg body weight (BW), 10 mg/kg BW, and 100 mg/kg BW) of baicalein were applied subcutaneously daily in three OVX groups.
Mm.
soleus, gastrocnemius, and longissimus were extracted; their diameter, area, relation to body, and muscle weights as well as number of capillaries per fibre were recorded.
In Mm.
soleus and gastrocnemius, the baicalein effect (increasing number of capillaries per fibre) was proportional to the dose applied.
The fibre diameters and area under baicalein treatment were significantly greater compared to OVX and NON-OVX groups.
In M.
longissimus, we observed a shift to type IIa fibres.
Serum creatine kinase levels were significantly lower in highest baicalein concentration group.
We conclude that baicalein can stimulate angiogenesis, though not fibre type-specific, in skeletal muscle and reduce the estrogen-related loss of fibre diameter and area in the skeletal muscle in rats.
Therefore, a protective effect of baicalein on muscle cells can be assumed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saul, D.& Kling, J. H.& Kosinsky, R. L.& Hoffmann, D. B.& Komrakova, M.& Wicke, M.…[et al.]. 2016. Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1109587
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saul, D.…[et al.]. Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1109587
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saul, D.& Kling, J. H.& Kosinsky, R. L.& Hoffmann, D. B.& Komrakova, M.& Wicke, M.…[et al.]. Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1109587
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109587
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر