Apolipoprotein C-II Mimetic Peptide Promotes the Plasma Clearance of Triglyceride-Rich Lipid Emulsion and the Incorporation of Fatty Acids into Peripheral Tissues of Mice
المؤلفون المشاركون
Remaley, Alan T.
Wolska, Anna
Komatsu, Tomohiro
Sakurai, Toshihiro
Amar, Marcelo J.
Sakurai, Akiko
Vaisman, Boris L.
Sviridov, Denis
Demosky, Stephen
Pryor, Milton
Ikewaki, Katsunori
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aim.
Plasma apolipoprotein C-II (apoC-II) activates lipoprotein lipase (LPL) and thus lowers plasma triglycerides (TG).
We previously reported that a human apoC-II mimetic peptide (C-II-a) decreased plasma TG in apoC-II mutant mice, as well as in apoE-knockout mice.
Because it is unknown what tissues take up free fatty acids (FFAs) released from TG after C-II-a peptide administration, we investigated in mice TG plasma clearance and tissue incorporation, using 3H-triolein as a tracer, with and without C-II-a treatment.
Methods and Results.
Intralipid® fat emulsion was labeled with 3H-triolein and then mixed with or without C-II-a.
Addition of the peptide did not alter mean particle size of the lipid emulsion particles (298 nm) but accelerated their plasma clearance.
After intravenous injection into C57BL/6N mice, the plasma half-life of the 3H-triolein for control and C-II-a treated emulsions was 18.3 ± 2.2 min and 14.8 ± 0.1 min, respectively.
In apoC-II mutant mice, the plasma half-life of 3H-triolein for injected control and C-II-a treated emulsions was 30.1 ± 0.1 min and 14.8 ± 0.1 min, respectively.
C57BL/6N and apoC-II mutant mice at 120 minutes after the injection showed increased tissue incorporation of radioactivity in white adipose tissue when C-II-a treated emulsion was used.
Higher radiolabeled uptake of lipids from C-II-a treated emulsion was also observed in the skeletal muscle of C57BL/6N mice only.
In case of apoC-II mutant mice, decreased uptake of radioactive lipids was observed in the liver and kidney after addition of C-II-a to the lipid emulsion.
Conclusions.
C-II-a peptide promotes the plasma clearance of TG-rich lipid emulsions in wild type and apoC-II mutant mice and promotes the incorporation of fatty acids from TG in the lipid emulsions into specific peripheral tissues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Komatsu, Tomohiro& Sakurai, Toshihiro& Wolska, Anna& Amar, Marcelo J.& Sakurai, Akiko& Vaisman, Boris L.…[et al.]. 2019. Apolipoprotein C-II Mimetic Peptide Promotes the Plasma Clearance of Triglyceride-Rich Lipid Emulsion and the Incorporation of Fatty Acids into Peripheral Tissues of Mice. Journal of Nutrition and Metabolism،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1183657
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Komatsu, Tomohiro…[et al.]. Apolipoprotein C-II Mimetic Peptide Promotes the Plasma Clearance of Triglyceride-Rich Lipid Emulsion and the Incorporation of Fatty Acids into Peripheral Tissues of Mice. Journal of Nutrition and Metabolism No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1183657
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Komatsu, Tomohiro& Sakurai, Toshihiro& Wolska, Anna& Amar, Marcelo J.& Sakurai, Akiko& Vaisman, Boris L.…[et al.]. Apolipoprotein C-II Mimetic Peptide Promotes the Plasma Clearance of Triglyceride-Rich Lipid Emulsion and the Incorporation of Fatty Acids into Peripheral Tissues of Mice. Journal of Nutrition and Metabolism. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1183657
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183657
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر