Inflammatory Markers Are Positively Associated with Serum trans-Fatty Acids in an Adult American Population

الملخص EN

Background and Aim.

The relationship between serum trans-fatty acids (TFAs) and systemic inflammation markers is unclear.

We investigated the association of serum TFAs with high sensitivity C-reactive protein (hs-CRP) and fibrinogen in adult Americans.

Methods.

The 1999 to 2000 National Health and Nutrition Examination Survey (NHANES) participants with measured data on hs-CRP and fibrinogen were included.

TFAs were measured via capillary gas chromatography and mass spectrometry using negative chemical ionization.

Analysis of covariance and multivariable-adjusted linear regression models were used to investigate the associations between these parameters, accounting for the survey design.

Results.

Of the 5446 eligible participants, 46.8% (n=2550) were men.

The mean age was 47.1 years overall: 47.8 years in men and 46.5 years in women (p=0.085).

After adjustment for age and sex, mean serum TFAs rose with the increasing quarters of hs-CRP and fibrinogen (both p<0.001).

In linear regression models adjusted for age, sex, race, education, marital status, body mass index, and smoking, serum TFAs were an independent predictor of plasma hs-CRP and fibrinogen levels.

Conclusion.

A high level of TFAs appears to be a contributor to an unfavourable inflammatory profile.

Because serum TFAs concentrations are affected by dietary TFA intake, these data suggest a possible contribution of TFAs intake modulation in the prevention of inflammation-related chronic diseases.