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Annotating the Function of the Human Genome with Gene Ontology and Disease Ontology
Joint Authors
Jin, Shuilin
Hu, Yang
Zhou, Wenyang
Ren, Jun
Dong, Lixiang
Cheng, Liang
Wang, Yadong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Increasing evidences indicated that function annotation of human genome in molecular level and phenotype level is very important for systematic analysis of genes.
In this study, we presented a framework named Gene2Function to annotate Gene Reference into Functions (GeneRIFs), in which each functional description of GeneRIFs could be annotated by a text mining tool Open Biomedical Annotator (OBA), and each Entrez gene could be mapped to Human Genome Organisation Gene Nomenclature Committee (HGNC) gene symbol.
After annotating all the records about human genes of GeneRIFs, 288,869 associations between 13,148 mRNAs and 7,182 terms, 9,496 associations between 948 microRNAs and 533 terms, and 901 associations between 139 long noncoding RNAs (lncRNAs) and 297 terms were obtained as a comprehensive annotation resource of human genome.
High consistency of term frequency of individual gene (Pearson correlation = 0.6401, p = 2.2 e - 16 ) and gene frequency of individual term (Pearson correlation = 0.1298, p = 3.686 e - 14 ) in GeneRIFs and GOA shows our annotation resource is very reliable.
American Psychological Association (APA)
Hu, Yang& Zhou, Wenyang& Ren, Jun& Dong, Lixiang& Wang, Yadong& Jin, Shuilin…[et al.]. 2016. Annotating the Function of the Human Genome with Gene Ontology and Disease Ontology. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097675
Modern Language Association (MLA)
Hu, Yang…[et al.]. Annotating the Function of the Human Genome with Gene Ontology and Disease Ontology. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097675
American Medical Association (AMA)
Hu, Yang& Zhou, Wenyang& Ren, Jun& Dong, Lixiang& Wang, Yadong& Jin, Shuilin…[et al.]. Annotating the Function of the Human Genome with Gene Ontology and Disease Ontology. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097675