Determination of 4-Methylimidazole in Ammonia Caramel Using Gas Chromatography–Tandem Mass Spectrometry (GC-MSMS)
Joint Authors
Wieczorek, Martyna N.
Przygoński, Krzysztof
Jeleń, Henryk H.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-29
Country of Publication
Egypt
No. of Pages
5
Abstract EN
One of Maillard reaction products formed in the production of ammonia caramel is 4(5)-methylimidazole (4-MeI) classified as carcinogen.
A method of 4-MeI determination based on ion-pair extraction and derivatisation with isobutyl chloroformate with subsequent gas chromatography-tandem mass spectrometry analysis was proposed.
Tandem mass spectrometry was applied to reduce the influence of matrix and increase the selectivity and sensitivity of the method.
Triple quadrupole GC-MS system was used for this study.
The collision energies were optimized for MRM mode.
The detection (LOD) and quantification limits (LOQ) of the elaborated method were 17 and 37.8 μg kg−1, respectively, repeatability was <15% RSD for analyzed caramel samples, and the recovery for 4-MeI was 101%.
Comparison of MS/MS with SIM detection on the same instrument proved almost 30 times lower LODs achieved by tandem mass spectrometry compared to SIM.
Described method can be routinely used for monitoring 4-MeI as a quality and safety marker in the production of ammonia caramel.
American Psychological Association (APA)
Wieczorek, Martyna N.& Przygoński, Krzysztof& Jeleń, Henryk H.. 2018. Determination of 4-Methylimidazole in Ammonia Caramel Using Gas Chromatography–Tandem Mass Spectrometry (GC-MSMS). Journal of Food Quality،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1185225
Modern Language Association (MLA)
Wieczorek, Martyna N.…[et al.]. Determination of 4-Methylimidazole in Ammonia Caramel Using Gas Chromatography–Tandem Mass Spectrometry (GC-MSMS). Journal of Food Quality No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1185225
American Medical Association (AMA)
Wieczorek, Martyna N.& Przygoński, Krzysztof& Jeleń, Henryk H.. Determination of 4-Methylimidazole in Ammonia Caramel Using Gas Chromatography–Tandem Mass Spectrometry (GC-MSMS). Journal of Food Quality. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1185225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185225