Studying the ameliorative effect of bee venom against damage and inflammation induced in gamma-irradiated rats
Joint Authors
Hamzah, R. G.
al-Shahat, A. N.
Munir, Ashraf M.
Source
Arab Journal of Nuclear Sciences and Applications
Issue
Vol. 52, Issue 1 (31 Jan. 2019), pp.178-184, 7 p.
Publisher
The Egyptian Society of Nuclear Science and Applications
Publication Date
2019-01-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
The aim of this study was focused on investigating the possible protective effect of Bee Venom (BV) against gamma radiation induced damage and inflammation in male rats.
Gamma-irradiation (6 Gy) resulted in a significant elevation in the level of tumor necrotic factor-alpha (TNF-α) , interleukin-6 (IL-6) , creatinine kinase-MB (CK-MB) and cardiac troponin I (cTnI), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), serum aspartate transaminase (AST) and alanine transaminase (ALT) , serum glucose, malondialdehyde (MDA) concentration and xanthine oxidase activity associated with remarkable decrease in insulin level, glutathione content (GSH) and the activity of xanthine dehydrogenase (XDH), superoxide dismutase (SOD) and catalase (CAT) in heart and liver tissues compared to control group.
Injection of BV (5ml/kg b.
wt.
/ day/6weeks) to γ-irradiated rats was found to offer protection against γ-irradiation induced oxidative stress and significantly ameliorated the changes occurred in the above investigated biochemical parameters.
It could be concluded that Bee venom clarified a modulatory role against gamma radiation induced oxidative damage and inflammation in the heart and liver tissues.
American Psychological Association (APA)
Hamzah, R. G.& Munir, Ashraf M.& al-Shahat, A. N.. 2019. Studying the ameliorative effect of bee venom against damage and inflammation induced in gamma-irradiated rats. Arab Journal of Nuclear Sciences and Applications،Vol. 52, no. 1, pp.178-184.
https://search.emarefa.net/detail/BIM-880517
Modern Language Association (MLA)
Hamzah, R. G.…[et al.]. Studying the ameliorative effect of bee venom against damage and inflammation induced in gamma-irradiated rats. Arab Journal of Nuclear Sciences and Applications Vol. 52, no. 1 (Jan. 2019), pp.178-184.
https://search.emarefa.net/detail/BIM-880517
American Medical Association (AMA)
Hamzah, R. G.& Munir, Ashraf M.& al-Shahat, A. N.. Studying the ameliorative effect of bee venom against damage and inflammation induced in gamma-irradiated rats. Arab Journal of Nuclear Sciences and Applications. 2019. Vol. 52, no. 1, pp.178-184.
https://search.emarefa.net/detail/BIM-880517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 182-184
Record ID
BIM-880517