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Phytochemical contents of salvia Grossheimii sosn. species extract and its protective effect on alcohol-induced fatty liver in rats
Joint Authors
Shahirudi, Sayyid Murtada Husayni
al-Sadiqbi, Mustafa
Karamian, Roya
Yari, Siamak
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 21, Issue 11 (30 Nov. 2019), pp.1-7, 7 p.
Publisher
Publication Date
2019-11-30
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Topics
- Oxidative Stress
- Aldehydes
- Phytochemicals
- Rats
- Plant extracts
- Salvia
- Antioxidants
- Fatty liver
- Irises
- Hydrogen peroxide
Abstract EN
Background: Researchers are interested in finding new agents with natural sources to cure oxidant-induced diseases.
Objectives: The study aimed at determining the antioxidant potential and protective effect of S.
grossheimii extract against alcoholinduced fatty liver.
Methods: This experimental study was performed in Bu-Ali Sina University, Hamedan, Iran.
In 2016 - 2017.
The sample size was determined to include 22 male Wistar rats (150 - 200 g) using Morgan’s table.
In total, 18 rats were divided into three different groups to receive (1) 1 mL water daily (control), (2) 1 mL alcohol daily (alcohol group), and (3) 1 mL extract (500 mg/kg) and alcohol daily (alcohol + extract).
Tissue and blood samples were obtained to determine the protective effect of S.
grossheimii extract against alcoholinduced fatty liver by histological and biochemical examinations.
The antioxidant activity of the extract was also assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.
Results: The extract possessed stronger antiradical activity (IC50: 0.102 0.002 mg/mL) than Vitamin C (IC50: 0.162 0.009 mg/mL).
The histological studies found liver tissue injury in group 2 and biochemical examinations indicated significantly lower (P < 0.05) total protein content (0.2050.002 mg/g.W.t) and superoxide dismutase (42.110.18Uprotein/min) enzymetissue activity than group 1 (TP: 0.236 0.003 mg/g.W.t and SOD: 62.22 0.90).
In addition, the levels of malondialdehyde (MDA) and hydrogen peroxide (H2O2) were significantly higher (P < 0.05) than group 1.
Also, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) serum enzyme levels (314.33 IU/L) were significantly higher (P < 0.05) in alcohol-treated animals than in group 1 (152.33 IU/L).
However, these injuries were remarkably lower (P < 0.05) in animals treated by the extract (group 3).
Conclusions: The results demonstrated the strong pharmaceutical activity of S.
grossheimii extract to apply as a new antioxidant agent, especially for the treatment of fatty liver.
American Psychological Association (APA)
Shahirudi, Sayyid Murtada Husayni& al-Sadiqbi, Mustafa& Karamian, Roya& Yari, Siamak. 2019. Phytochemical contents of salvia Grossheimii sosn. species extract and its protective effect on alcohol-induced fatty liver in rats. Iranian Red Crescent Medical Journal،Vol. 21, no. 11, pp.1-7.
https://search.emarefa.net/detail/BIM-910602
Modern Language Association (MLA)
Shahirudi, Sayyid Murtada Husayni…[et al.]. Phytochemical contents of salvia Grossheimii sosn. species extract and its protective effect on alcohol-induced fatty liver in rats. Iranian Red Crescent Medical Journal Vol. 21, no. 11 (Nov. 2019), pp.1-7.
https://search.emarefa.net/detail/BIM-910602
American Medical Association (AMA)
Shahirudi, Sayyid Murtada Husayni& al-Sadiqbi, Mustafa& Karamian, Roya& Yari, Siamak. Phytochemical contents of salvia Grossheimii sosn. species extract and its protective effect on alcohol-induced fatty liver in rats. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 11, pp.1-7.
https://search.emarefa.net/detail/BIM-910602
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in .
Record ID
BIM-910602